Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9
Abstract Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters.A TLR5 agonist, entolimod, is among the most powerful experimental radiation countermeasures and shows efficacy in rodents and non-human primates as a prophylactic (radioprotection) and treatment (radiomitigation) modality.While the prophylactic acti